Chii chinonzi Nitric Oxide?
Nitric oxide imhepo inogadzirwa nemasero anobatanidzwa mukuzvimba kunokonzerwa neallergy kana eosinophilic asthma.
Chii chinonzi FeNO?
Kuongororwa kweFractional exhaled Nitric Oxide (FeNO) inzira yekuyera huwandu hwenitric oxide mumhepo inoburitswa. Kuongororwa uku kunogona kubatsira pakuongorora asthma nekuratidza huwandu hwekuzvimba mumapapu.
Kushandiswa kweFeNO mukurapa kwezvirwere zvepfungwa
FeNO inogona kupa rubatsiro rusingapindi muropa rwekutanga rwechirwere cheasthma, ATS neNICE vachikurudzira kuti chive chikamu chemirayiridzo yavo yazvino uye maalgorithms ekuongorora chirwere.
| Vakuru | Vana | |
| ATS (2011) | Yakakwirira: >50 ppb Pakati nepakati: 25-50 ppb Yakaderera:<25 ppb | Yakakwirira: >35 ppb Pakati nepakati: 20-35 ppb Yakaderera:<20 ppb |
| GINA (2021) | ≥ 20 ppb | |
| NICE (2017) | ≥ 40 ppb | >35 ppb |
| Kubvumirana kweScotland (2019) | >40 ppb varwere vasina ruzivo rweICS Varwere vane >25 ppb vari kutora ICS |
Zvidimbu: ATS, American Thoracic Society; FeNO, fractional exhaled nitric oxide; GINA, Global Initiative for Asthma; ICS, inhaled corticosteroid; NICE, National Institute for Health and Care Excellence.
Nhungamiro dzeATS dzinotsanangura mazinga eFeNO akakwira, ari pakati nepakati, uye ari pasi muvanhu vakuru se >50 ppb, 25 kusvika 50 ppb, uye <25 ppb, zvichiteerana. Pavana, mazinga eFeNO akakwira, ari pakati nepakati, uye ari pasi anotsanangurwa se >35 ppb, 20 kusvika 35 ppb, uye <20 ppb (Tafura 1). ATS inokurudzira kushandiswa kweFeNO kutsigira kuongororwa kweasthma uko kunodiwa humbowo hwakajeka, kunyanya mukuongororwa kwekuzvimba kweeosinophilic. ATS inotsanangura kuti mazinga eFeNO akakwira (>50 ppb muvanhu vakuru uye >35 ppb muvana), kana ichitsanangurwa mukiriniki, inoratidza kuti kuzvimba kweeosinophilic kuripo nemhinduro ye corticosteroid muvarwere vane zviratidzo, nepo mazinga akaderera (<25 ppb muvanhu vakuru uye <20 ppb muvana) anoita kuti mazinga aya asingatarisirwi uye ari pakati anofanirwa kududzirwa nekungwarira.
Nhungamiro dzeNICE dziripo, dzinoshandisa mwero wekudzikisa weFeNO wakaderera pane ATS (Tafura 1), dzinokurudzira kushandiswa kweFeNO sechikamu chekuongorora apo kuongororwa kweasthma kuri kutariswa muvanhu vakuru kana kuti pane kusava nechokwadi kwekuongorora muvana. Mazinga eFeNO anodudzirwa zvakare mune zvekurapa uye kumwe kuongororwa, senge kuyedzwa kwebronchial provocation kunogona kubatsira kuongororwa nekuratidza kusateerera kwemhepo. Nhungamiro dzeGINA dzinobvuma basa reFeNO mukuona kuzvimba kweeosinophilic muasthma asi parizvino hadzioni basa reFeNO mu algorithms yekuongorora asthma. Scottish Consensus inotsanangura kudzikisa zvichienderana nekuratidzwa kwesteroid nezviratidzo zvakanaka zve >40 ppb muvarwere vasina steroid uye >25 ppb kune varwere vari paICS.
Nguva yekutumira: Kurume-31-2022