Chii chinonzi Nitric oxide?
Nitric oxide igasi rinogadzirwa nemasero anobatanidzwa mukuzvimba kunoenderana neallergic kana eosinophilic asthma.
Chii chinonzi FeNO?
A Fractional exhaled Nitric Oxide (FeNO) bvunzo inzira yekuyera huwandu hwenitric oxide mukufemerwa.Muedzo uyu unogona kubatsira nekuongororwa kweasthma nekuratidza huwandu hwekuzvimba mumapapu.
Clinical Utility yeFeNO
FeNO inogona kupa chibvumirano chisingaiti chekutanga kuongororwa kweasthma neATS uye NICE ichikurudzira sechikamu chemitemo yavo yemazuva ano uye diagnostic algorithms.
| Vakuru | Vana | |
| ATS (2011) | Pamusoro:> 50 ppb Pakati: 25-50 ppb Pazasi: <25 ppb | Pamusoro:> 35 ppb Pakati: 20-35 ppb Pazasi: <20 ppb |
| GINA (2021) | ≥ 20 ppb | |
| NICE (2017) | ≥ 40 ppb | > 35 pb |
| Kubvumirana kweScottish (2019) | > 40 ppb ICS-vasingazivi varwere > 25 ppb varwere vanotora ICS |
Madimburiko: ATS, American Thoracic Society;FeNO, fractional ex-haled nitric oxide;GINA, Global Initiative yeAsthma;ICS, inhaled corticosteroid;NICE, National Institute for Health uye Care Excellence.
Mirayiridzo yeATS inotsanangura mazinga epamusoro, epakati, uye akaderera eFeNO muvakuru se> 50 ppb, 25 kusvika ku50 ppb, uye <25 ppb, zvichiteerana.Paunenge uri muvana, yakakwirira, yepakati, uye yakaderera FeNO mazinga anotsanangurwa se> 35 ppb, 20 kusvika 35 ppb, uye <20 ppb (Table 1).IATS inokurudzira kushandiswa kweFeNO kutsigira kuongororwa kweasthma apo humbowo hunodiwa hunodiwa, kunyanya pakuongororwa kweiyosinophilic kuzvimba.IATS inotsanangura kuti yakakwirira yeFeNO mazinga (> 50 ppb muvakuru uye> 35 ppb muvana), kana ichidudzirwa mumamiriro ehutano, inoratidza kuti eosinophilic kuzvimba kunowanikwa necorticosteroid kupindura muvarwere vane zviratidzo, nepo mazinga akaderera (<25 ppb muvakuru. uye <20 ppb muvana) ita izvi zvisingaite uye mazinga epakati anofanira kududzirwa nekuchenjerera.
Ikozvino NICE nhungamiro, iyo inoshandisa yakaderera FeNO kucheka-kubvisa mazinga pane ATS (Tafura 1), inokurudzira kushandiswa kweFeNO sechikamu chebasa rekuongorora apo kuongororwa kweasthma kuri kutariswa kune vanhu vakuru kana uko kune kusava nechokwadi kwekuongorora muvana.FeNO mazinga anodudzirwa zvakare mune yekiriniki mamiriro uye kumwe kuyedzwa, senge bronchial provocation test inogona kubatsira kuongororwa nekuratidza airway hyperresponsiveness.Mirayiridzo yeGINA inobvuma basa reFeNO mukuziva eosinophilic kuzvimba muasthma asi parizvino haioni basa reFeNO muasthma diagnostic algorithms.The Scottish Consensus inotsanangura kucheka-kubvisa maererano ne steroid exposure ine maitiro akanaka e> 40 ppb mu steroid-naive varwere uye> 25 ppb kune varwere ve ICS.
Nguva yekutumira: Mar-31-2022